(Collecta: S. Vitalis)
(Image source)
From the Churches of Rome wiki:
The first Christian place of worship was built here in the 4th century. It was probably the titulus of Pope Caius (283–296) - the tituli were the first parish churches in Rome. Caius was St Susanna's uncle, and tradition claims that the church stands on the site of her martyrdom.
A church was built in 330, and named San Caio after the owner of the first chapel. In 590, the church was rededicated to St Susanna because of her growing popularity.
Pope Leo III (795-816) had the church redecorated...
It was rebuilt under Sixtus IV (1471-1484), and again by Cardinal Girolamo Rusticucci between 1593 and 1603. The architect was Carlo Maderno.
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In the crypt are also parts of a 3rd century house, which may have been Susanna's home.
